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    Its one of the older anti-depressants and it has never been that widely used at
    least in the UK (I can’t comment on other countries.) It’s one of the anti-
    depressants that has an effect on the heart so that needs to be monitored. It
    probably has a worse side effect profile than newer drugs. But any decision to
    use  A prospective, double-blind, placebo controlled, crossover design was used that
    included 2, 3-week periods with clomipramine and placebo. During treatment
    phases subjects took either 25 mg. clomipramine or placebo as needed, that is
    12 to 24 hours before anticipated sexual activity (coitus or masturbation).
    Subjects 
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    A prospective, double-blind, placebo controlled, crossover design was used that
    included 2, 3-week periods with clomipramine and placebo. During treatment
    phases subjects took either 25 mg. clomipramine or placebo as needed, that is
    12 to 24 hours before anticipated sexual activity (coitus or masturbation).
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    Your doctor may want to take some blood tests and check your heart and blood
    pressure from time to time. This helps to prevent unwanted side effects. Contact
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    symptoms at any time during treatment with Anafranil: thoughts about suicide or 
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    If you have diabetes you may need to check your blood glucose more frequently.
    This is because clomipramine can alter the levels of sugar in your blood. Your
    doctor will advise you about this. If you are due to have any medical treatment,
    tell the person carrying out the 
    Its one of the older anti-depressants and it has never been that widely used at
    least in the UK (I can’t comment on other countries.) It’s one of the anti-
    depressants that has an effect on the heart so that needs to be monitored. It
    probably has a worse side effect profile than newer drugs. But any decision to
    use 
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    Anafranil is a tricyclic antidepressant. It affects chemicals in the brain that may be
    unbalanced. Anafranil is used to treat symptoms of obsessive-compulsive
    disorder (OCD) such as recurrent thoughts or feelings and repetitive actions.
    Anafranil may also be used for purposes not listed in this medication guide.
    Insomnia and 
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    The mechanism of action of the drugs effective in treating OCD (clomipramine, a
    non-selective serotonin reuptake inhibitor, and the selective serotonin reuptake
    inhibitors [SSRIs]: citalopram, fluoxetine, fluvoxamine, sertraline and paroxetine)
    has given rise to the hypothesis that deficient serotonin function is a key element
     
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    Serum Desmethylclomipramine and Clomipramine Levels and Their Ratio
    Among Patients With Obsessive-Compulsive Disorder Treated With Intravenous
    Clomipramine*. 1. Clomipramine Collaborative Study Group, Clomipramine in
    the treatment of patients with obsessive-compulsive disorder. Arch Gen
    Psychiatry. 1991 
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